CRN-BC Exam Information and Outline
Clinical Research Nurse Certification
Syllabus Update Checked on: November 10, 2026
CRN-BC Exam Syllabus & Study Guide
Before you start practicing with our exam simulator, it is essential to understand the
official CRN-BC exam objectives. This course outline serves as your roadmap.
The information below reflects the 2026 syllabus defined by
CRNCC.
Below are complete topics detail with latest syllabus and course outline, that will help you good knowledge about exam objectives and topics that you have to prepare. These contents are covered in questions and answers pool of exam.
- Exam Format
- Computer-based multiple-choice examination
- Human Subject Protection
- Informed consent process and documentation
- IRB/ethics committee oversight; vulnerable populations
- Belmont Report, Declaration of Helsinki, Common Rule
- Care Coordination and Continuity
- Protocol-driven patient care across settings
- Participant recruitment, screening and retention
- Clinical Practice
- Investigational drug and device administration
- Adverse event identification, grading and reporting
- Specimen collection and handling
- Study Management
- Protocol adherence, source documentation and data integrity
- Good Clinical Practice (ICH E6) and FDA regulations
- Monitoring visits and audits
- Contributing to the Science
- Research design and phases of clinical trials
- Evidence-based practice and dissemination
- Professional Practice
- Ethics, advocacy, leadership and collaboration