USMLE Exam Information and Outline
United States Medical Licensing Examination Step 1
Syllabus Update Checked on: August 28, 2026
USMLE Exam Syllabus & Study Guide
Before you start practicing with our exam simulator, it is essential to understand the
official USMLE exam objectives. This course outline serves as your roadmap.
The information below reflects the 2026 syllabus defined by
USMLE.
Below are complete topics detail with latest syllabus and course outline, that will help you good knowledge about exam objectives and topics that you have to prepare. These contents are covered in questions and answers pool of exam.
USMLE United States Medical Licensing Examination Step 1
- General Principles of Foundational Science
- Immune System
- Blood & Lymphoreticular System
- Behavioral Health
- Nervous System & Special Senses
- Skin & Subcutaneous Tissue
- Musculoskeletal System
- Cardiovascular System
- Respiratory System
- Gastrointestinal System
- Renal & Urinary System
- Pregnancy, Childbirth & the Puerperium
- Female Reproductive System & Breast
- Male Reproductive System
- Endocrine System
- Multisystem Processes & Disorders
- Biostatistics, Epidemiology & Population Health
- Interpretation of the Medical Literature
- Social Sciences
- Biochemistry & Molecular Biology
- DNA structure and replication
- DNA repair
- Epigenetics
- Transcription
- Translation
- Protein synthesis
- Protein degradation
- Golgi apparatus
- Rough endoplasmic reticulum
- Protein structure
- Enzyme kinetics
- ATP generation
- Electron transport chain
- Cell biology
- Cell signaling
- Cell cycle
- Apoptosis
- Necrosis
- Cancer biology
- Oncogenes
- Tumor suppressor genes
- Metastasis
- Cytoskeleton
- Organelles
- Receptors
- Human Development & Genetics
- Pedigree analysis
- Inheritance patterns
- Hardy-Weinberg equilibrium
- Founder effects
- Gene therapy
- Genetic testing
- Genetic counseling
- Penetrance
- Genetic heterogeneity
- Inflammation & Tissue Repair
- Acute inflammation
- Chronic inflammation
- Cytokines
- Complement
- Leukocyte migration
- Wound healing
- Fibrosis
- Angiogenesis
- Scar formation
- Pharmacology
- Pharmacokinetics
- Pharmacodynamics
- Drug metabolism
- Drug interactions
- Agonists
- Antagonists
- Toxicology
- Signal transduction
- Microbiology
- Bacteria
- Viruses
- Fungi
- Parasites
- Prions
- Antimicrobial drugs
- Antiviral drugs
- Antifungal drugs
- Antiparasitic drugs
- Normal Human Development
- Infancy
- Childhood
- Adolescence
- Adulthood
- Aging
- Preventive medicine
- Vaccinations
- Nutrition
- Screening
- Exercise
- Health maintenance