ASPEX-PA Exam Format | Course Contents | Outline | Syllabus | Objectives

ASPEX-PA Exam Syllabus & Study Guide

Before you start practicing with our exam simulator, it is essential to understand the official ASPEX-PA exam objectives. This course outline serves as your roadmap.

The information below reflects the 2026 syllabus defined by ABA.

Below are complete topics detail with latest syllabus and course outline, that will help you good knowledge about exam objectives and topics that you have to prepare. These contents are covered in questions and answers pool of exam.

I. BASIC SCIENCE - Anatomy - General Development - Airway - Body habitus - Water, volume, and blood composition - Anatomy for Procedures - Airway management - Central neuraxial blockade - Peripheral nerve blockade - Vascular cannulation - Physics and Anesthesia Equipment - Respiration - Breathing circuits - Ventilation devices and techniques - Methods for Monitoring - Brain, spinal cord, and neuromuscular function - Cardiac rhythm and vascular pressures - Oxygenation, gas concentration, and ventilation - Temperature - Ultrasound: Physics and Clinical applications - Anesthetic Pharmacology - Pharmacokinetics and Pharmacodynamics - Blood-brain barrier - Drug absorption - Drug distribution - Neuromuscular system - Biotransformation and excretion - Pharmacogenetics - Non-opioid Analgesics - Opioid Analgesics - Sedative and Anxiolytic Agents - Anti-emetics - Inhalation Anesthetics - Local Anesthetics - Neuromuscular Blocking and Reversal Agents - Sympathetic and Parasympathetic Agents - Agents Affecting Coagulation II. ORGAN-BASED BASIC AND CLINICAL SCIENCES - Respiratory System - Anatomy and Physiology - Prenatal and postnatal development - Respiratory mechanics, ventilation, and lung volumes - Oxygen transport - Surfactant, surface activity, and lung mechanics - Lung physiology - surfactant and surface tension - metabolism - ventilation / perfusion matching - Clinical Sciences - Obstructive disease - upper airway - tracheobronchial - parenchymal - Restrictive disease - pleural - neurologic - musculoskeletal - Anesthesia for thoracic procedures - one lung ventilation - video-assisted thoracoscopy - mediastinal masses - chest wall surgery / reconstruction - lung transplantation - Cardiovascular System - Anatomy and Physiology - Prenatal and postnatal development - Fetal, transitional, and adult circulation - Benign heart murmur - Clinical Science - General considerations - cardiovascular effects on anesthetic uptake and delivery - anesthetic effects on the cardiovascular system - vasoactive medications - Disease states - acyanotic lesions - cyanotic lesions - palliative procedures - pulmonary hypertension - infectious diseases - cardiomyopathies - pericardial disease - intracardiac masses - arrhythmic lesions - heart transplantation - Anesthesia for cardiac procedures - complete anatomic and physiological repairs - single ventricle procedures - palliation surgery - management and consequences of cardiopulmonary bypass - deep hypothermic circulatory arrest - anesthesia for pacemaker / implantable cardiac defibrillator insertion and replacement - anesthesia for diagnostic, interventional and electrophysical procedures - Anesthesia for the adult with congenital heart disease - Cardiopulmonary resuscitation - Anesthesia for non-cardiac procedures in child with congenital heart disease - Central and Peripheral Nervous Systems - Anatomy and Physiology - Prenatal and postnatal development - brain, fontanelles, cranial sutures, and spinal cord - myelinization, autonomic nervous systems, and pain pathways - neurodegenerative changes after anesthesia - Neurophysiology - Clinical Science - General considerations - intracranial pressure and blood flow - pharmacology of diuretics, steroids, and anticonvulsant medications - Disease states - autism, developmental delay, and ADHD - hydrocephalus - tumors - seizure disorders - cerebrovascular disorders - open and closed head injuries - spinal cord disorders - neurodegenerative disorders - spasticity - Chiari malformations - Anesthesia for neurosurgical procedures - seizure surgery - intracranial tumors and vascular lesions - craniofacial reconstruction / cranioplasty - meningomyelocele / spinal surgery - neurologic imaging - Gastrointestinal System - Anatomy and Physiology - Prenatal and postnatal development - Clinical Science - Esophageal, stomach and intestine disorders - abdominal wall defects - intestinal rotation defects - atresias, stenoses and webs - inflammatory states - duplications and cysts - hernias - necrotizing enterocolitis - Liver, biliary tract and spleen disorders - Anorectal disorders - Morbid obesity / bariatric surgery - Gastrointestinal endoscopy - Esophageal / gastrointestinal foreign bodies - Liver, intestinal, and multivisceral transplantation - Renal/Urinary - Anatomy and Physiology - Prenatal and postnatal development - Homeostasis functions - Clinical Science - Renal failure - Phimosis and hypospadias - Ureteropelvic junction obstruction - Vesicoureteral reflux - Bladder exstrophy - Renal transplantation - Endocrine/Metabolic - Anatomy and Physiology - Prenatal and postnatal development - Puberty and variants - Clinical Science - Adrenal disorders - Diabetes mellitus - Diabetes insipidus - Disorders of sodium regulation - Pheochromocytoma - Thyroid disorders - 22q.11 deletion syndrome (DiGeorge) - Hematology/Oncology - Anatomy and Physiology - Prenatal and postnatal development - Clinical Science - Hematology - anemias - coagulation disorders - Oncology - leukemia - neuroblastoma - retinoblastoma - sarcomas / osteosarcomas - Wilms tumor - Chemotherapeutic agents and side effects - Radiotherapy - Bone marrow and stem cell transplants - graft versus host disease - Immunologic disorders (congenital and acquired) - Genetics - Anatomy and Physiology - Clinical Sciences - Chromosomal abnormalities - Craniofacial syndromes - Effects of environmental agents - Endocrine disorders - Immunologic disorders - Inborn errors of metabolism - Malignant hyperthermia - Mitochondrial myopathies - Myopathic disorders - Myotonias - Muscular dystrophies - Neurologic disorders - Overgrowth syndromes - Osteochondrodysplastic syndromes - Skin and connective tissue disorders III. CLINICAL SUBSPECIALTIES - Fetal - Neonatal - Painful Disease States - Otolaryngology - Plastic and Oral-Maxillary Facial Surgery - Ophthalmology - Orthopedic Surgery - Trauma and Burns IV. CLINICAL SCIENCE OF ANESTHESIA - Evaluation and Preoperative Preparation of the Pediatric Patient - General Considerations of the Perioperative Period - Regional Anesthesia and Analgesia - General Anesthesia - Complications of Anesthesia - Special Techniques and Situations - Postoperative Period - Monitored Anesthesia Care and Sedation - Acute and Chronic Pain Management V. SPECIAL PROBLEMS OR ISSUES - Special Surgical Procedures - Professional Issues - Principles of Biostatistics and Pediatric Study Design - Substance Abuse - Ethics and Medico-Legal Issues - Practice Management - Quality Improvement and Patient Safety - Diversity, Equity, and Inclusion (DEI) in Health Care - Healthcare Disparities