
CCRN-Neonatal Exam Information and Outline
Critical Care Register Nurse - Neonatal
CCRN-Neonatal Exam Syllabus & Study Guide
Before you start practicing with our exam simulator, it is essential to understand the official CCRN-Neonatal exam objectives. This course outline serves as your roadmap, breaking down exactly which technical domains and skills will be tested. By reviewing the syllabus, you can identify your strengths and focus your study time on the areas where you need the most improvement.
The information below reflects the latest 2026 course contents as defined by AACN. We provide this detailed breakdown to help you align your preparation with the actual exam format, ensuring there are no surprises on test day. Use this outline as a checklist to track your progress as you move through our practice question banks.
Below are complete topics detail with latest syllabus and course outline, that will help you good knowledge about exam objectives and topics that you have to prepare. These contents are covered in questions and answers pool of exam.
Exam Code: CCRN-Neonatal
Exam Name: Critical Care Register Nurse (Neonatal)
Total Questions: 150 multiple-choice questions.
Scored Questions: 125 scored- 25 unscored
Time Allotted: 3 hours
Passing Score: 84 correct answers out of the 125 scored questions.
Cardiovascular
- Acquired cardiac conditions
- Alteration in the transition to extrauterine life(e.g.- PDA- PFO- PPHN)
- Cardiac tamponade
- Congenital heart defects
- Dysrhythmias
- Heart failure (e.g.- high output- congestive-secondary)
- Hemodynamic instability
- Surgery
Respiratory
- Acute respiratory distress and/or failure
- Alteration in the transition to extrauterine life(e.g.- surfactant deficiency- secondary apnea)
- Apnea of prematurity
- Aspiration (e.g.- meconium- secretions- milk-gastric contents)
- Chronic conditions (e.g.- CLD/BPD- PIE)
- Congenital anomalies (e.g.- CDH- TEF-EA-choanal atresia- tracheal malacia/stenosis/atresia- CPAM- chylothorax)
- Infection (bacterial- viral- and fungal)
- Pleural space abnormalities (e.g.-pneumothorax- hemothorax- empyema-pleural effusions)
- Pulmonary hemorrhage
- Pulmonary hypertension (e.g.- PPHN-structural failure)
- Respiratory distress syndrome (RDS)
- Surgery
- Transient tachypnea of the newborn (TTN)
Endocrine- Hematology/Immunology- GI- Renal/GU- Integumentary
- Endocrine
- Adrenal disorders
- Calcium homeostatis disorders
- Glucose homeostasis (hypo- andhyperglycemia)
- Metabolism disorders (e.g.- glucose-protein- fat)
- Thyroid disorders
- Hematology and Immunology
- Blood cell disorders (e.g.- anemias-polycythemia- sickle cell disease-leukopenia)
- Coagulopathies (e.g.- DIC-thrombocytopenias- hemorrhagic diseaseof the newborn- factor deficiencies)
- Hemolytic disease of the newborn (e.g.- Rhincompatibilities- ABO incompatibilities)
- Gastrointestinal
- Abnormalities - congenital or acquired (e.g.-omphalocele- gastroschisis- malrotation/volvulus- imperforate anus- Hirschsprungdisease- intussusception- pyloric stenosis-atresias)
- Gastroesophageal reflux
- Hepatic failure (e.g.- portal hypertension-biliary atresia- cholestasis)
- Necrotizing enterocolitis (NEC)
- Nutritional conditions
- Intolerance (e.g.- feeding- proteinabsorption- milk allergy)
- Malabsorption
- Surgery
- Renal and Genitourinary
- Conditions - congenital and acquired (e.g.-hypospadias- polycystic kidney disease-hydronephrosis- bladder exstrophy- posterior urethral valves- ambiguousgenitalia- AKI- CKD)
- Infections
- Surgery
- Integumentary
- Complications related to neonatal skin (e.g.-injury- transepidermal water loss- contactdermatitis)
- Congenital abnormalities(e.g.- epidermolysis bullosa- skin tags-hemangiomas)
- Diaper dermatitis
- Infection (bacterial- viral- and fungal)
- IV infiltration/extravasation
- Skin conditions associated with gestationalage
- Wounds (non-surgical and surgical)
Psychosocial
- Musculoskeletal
- Acquired conditions (e.g.- osteopenia-fractures- brachial plexus injury- infection)
- Congenital conditions (e.g.- craniofacial-limb- muscle- spine- osteogenesisimperfecta)
- Neurological
- Congenital abnormalities (e.g.- AVmalformation- myelomeningocele-encephalocele- hydrocephalus)
- Hemorrhage (e.g.- extracranial- intracranial-intraventricular)
- Infection (bacterial- viral- and fungal)
- Ischemic insult (e.g.- stroke- periventricularleukomalacia- HIE)
- Seizures
- State dysregulation (e.g.- stress- pain-agitation)
- Surgery
- Behavioral and Psychosocial
- Alterations in family systems (e.g.-engagement- resource limitations- caregiverconfidence- PTSD- postpartum mooddisorder)
- Abuse/neglect/maltreatment
- Families in crisis (e.g.- grief- lack of coping-violent behavioral escalation- obstructionof care)
- Culture/communication/language
Multisystem
- Acid-base and fluid/electrolyte imbalance
- Birth trauma
- Conditions requiring advanced therapy(e.g.- ECMO- CRRT- dialysis- therapeutichypothermia)
- Delay in growth and/or developmentalmilestones
- Genetic conditions
- Metabolic
- Syndromes (e.g.- Turner- Noonan- BeckwithWiedemann- Prader-Willi- Angelman-CHARGE)
- Trisomies (13- 18- 21)
- Healthcare-acquired conditions (e.g.- CAUTI-CLABSI- VAE- HAPI- PIVIE- MDRO)
- Hydrops fetalis
- Hyperbilirubinemia
- Infant of a diabetic mother (IDM)
- Life-threatening maternal/fetal complications(e.g.- eclampsia- HELLP syndrome- maternalfetal transfusion- placental abruption- placenta previa)
- 1Multi-organ failure
- Sensory impairment (e.g.- retinopathy ofprematurity- glaucoma- congenital hearingimpairment)
- Sepsis (early and late onset)
- Sequences (e.g.- VACTERL- Pierre Robin)
- Shock states (e.g.- hypovolemic- septic-cardiogenic- obstructive)
- Terminal conditions (e.g.- end-of-life- palliativecare- death and dying)
- Thermoregulation
- Toxin/drug exposure (e.g.- withdrawal frommaternal or iatrogenic substances- fetal alcoholspectrum syndrome)
General
- Anticipate and recognize signs and systems ofevolving patient condition
- Assess and monitor based on patient's gestationalage
- Identify and monitor normal and abnormaldiagnostic test results (e.g.- labs- radiology-pathology)
- Implement interventions to keep the neonatessafe (e.g.- transport- security- safe sleep- safe infanthandling- infection prevention)
- Manage equipment and/or devices relevant topatient care
- Manage patients receiving enteral/oral andparenteral medications based on gestational age andweight
- Provide age-appropriate developmental care
- Provide care for families considering equity- diversity-and inclusion
- Provide pre- intra- and post-operative/proceduralcare
- Recognize indications for advanced therapies andfollow protocols
- Recognize signs and systems of emergencies- initiateinterventions- and seek assistance as needed
- Recognize the impact of genetics on postnatal care
- Cardiovascular
- Identify- interpret and monitor cardiac rhythms
- Recognize normal fetal circulation and transition toextrauterine life
- Recognize signs and symptoms of hemodynamicinstability
- Recognize indications for and manage patients with/requiring:
- congenital cardiovascular abnormalities
- hemodynamic monitoring (non-invasive andinvasive)
- patent ductus arteriosus (PDA)
- pharmacologic and mechanic cardioversion
- vascular access (e.g.- PIVS- UVC- UAC- Midline-PICC- tunneled- non-tunneled)
- Respiratory
- Interpret blood gas results
- Manage medications and monitor patients requiringrapid sequence intubation (RSI)
- Prevent complications related to respiratory support
- Recognize indications for and manage patients with/requiring:
- alternative airways (e.g.- endotracheal tube-laryngeal mask airway (LMA))
- assisted ventilation (traditional and highfreqency)
- chest tubes
- congenital respiratory/pulmonaryabnormalities
- non-invasive positive pressure ventilation(e.g.- CPAP- NIPPV- high-flow nasal cannula)
- respiratory monitoring devices (e.g.- SP02-SV02- ETC02)
- therapeutic gases (e.g.- oxygen- nitric oxide-heliox- CO2)
- thoracentesis
- tracheostomy
- Hematology and Immunology
- Recognize indications for and manage patients with/requiring:
- bleeding disorders and other bloodpathophysiology
- blood conservation techniques
- congenital hematology/immunologyabnormalities
- transfusion of blood products
- Neurological
- Implement strategies for neurologic protection/promotion
- Recognize indications for and manage patients with/requiring:
- congenital neurological abnormailities
- neurologic monitoring devices and drains (e.g.-ICP- ventricular drain)
- pain (non-pharmacologic and pharmacologic)
- sedation (e.g.- procedural- intermittent-continuous)
- therapeutic hypothermia
- Integumentary
- Recognize indications for- and manage patients with/requiring:
- altered skin integrity based on gestational age
- congenital integumentary abnormalities
- infiltration/extravasation
- preventative and therapeutic intervention(e.g.- neonatal skin care- humidity- bathing-adhesives)
- therapeutic devices (e.g.- wound VACs- pressurereduction surfaces- ostomy device)
- Gastrointestinal
- Recognize indications for and manage patients with/requiring:
- congenital GI abnormalities
- enteral and parenteral nutrition
- enteral tubes (gastic and post-pyloric)
- feeding diffulties and disorders
- lactation support
- necrotizing enterocolities (NEC)
- peritoneal drains
- transition to oral feedings
- Renal and Genitourinary
- Recognize indications for and manage patients with/requiring:
- congenital renal and genitourinaryabnormalities
- fluid/electrolyte management
- diagnostic procedures (e.g.- renal biopsy-ultrasound)
- Multisystem
- Follow protocol for newborn screening (e.g.- car seattesting- metabolic- hearing and congenital heartdisease)
- Recognize the impact of developmental physiologyon postnatal care
- Promote thermoregulation based on gestational age
- Recognize indications for and manage patients with/requiring:
- birth trauma
- early and late onset sepsis
- acid-base and fluid/electrolyte management
- palliative and end of life care
- toxin/drug exposure (e.g.- withdrawal frommaternal or iatrogenic substances- fetal alcoholspectrum syndrome)
- Behavioral and Psychosocial
- Faciliate progressive family involvement in care
- Recognize indications of stress and provide supportto family
- Respond to behavioral emergencies (e.g.- nonviolentcrisis intervention- de-escalation techniques)
- Provide care for diverse families (e.g.- cultural-spiritual- LGBTQ+ community)
- Recognize the impacts of social determinants ofhealth
- Facilitate trauma informed care for families